MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells.

Slack, Andrew D; Chen, Zaowen; Ludwig, Andrew D; Hicks, John; Shohet, Jason M

Slack, Andrew D; Chen, Zaowen; Ludwig, Andrew D; Hicks, John; Shohet, Jason M.

Affiliation

Slack AD; Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

Cancer Res ; 67(6): 2448-55, 2007 Mar 15.

Article in En | MEDLINE | ID: mdl-17363562

Subject(s)

Centrosome/physiology; Neuroblastoma/genetics; Nuclear Proteins/genetics; Oncogene Proteins/genetics; Proto-Oncogene Proteins c-mdm2/genetics; Tumor Suppressor Protein p53/antagonists & inhibitors; DNA Damage; Genes, p53; Genomic Instability; HCT116 Cells; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma/metabolism; Nuclear Proteins/biosynthesis; Nuclear Proteins/metabolism; Oncogene Proteins/biosynthesis; Oncogene Proteins/metabolism; Promoter Regions, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53/biosynthesis; Tumor Suppressor Protein p53/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Tumor Suppressor Protein p53 / Oncogene Proteins / Centrosome / Proto-Oncogene Proteins c-mdm2 / Neuroblastoma Limits: Humans Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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