Host innate immune response to Mycobacterium tuberculosis.
J Clin Immunol
; 27(4): 347-62, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17364232
ABSTRACT
This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Host-Pathogen Interactions
/
Immunity, Innate
/
Macrophages
/
Mycobacterium tuberculosis
Limits:
Humans
Language:
En
Journal:
J Clin Immunol
Year:
2007
Document type:
Article
Affiliation country:
United States