1-O-alkylglycerol stabilized carbamazepine intravenous o/w nanoemulsions for drug targeting in mice.
J Drug Target
; 15(2): 154-61, 2007 Feb.
Article
in En
| MEDLINE
| ID: mdl-17365287
Carbamazepine (CBZ) is used in the treatment of generalized tonic clonic and partial seizures. In seizure disorder the focal point of treatment is brain. At present no commercial parenteral formulation of CBZ is available. We developed o/w nanoemulsions of CBZ stabilized by 1-O-alkylglycerol/lecithin for intravenous administration and evaluated the brain targeting potential of these formulations. The nanoemulsions were characterized for globule size, zeta potential (ZP), CBZ content and in vivo tissue distribution in mice. The in vivo data revealed a significant uptake of CBZ in all tissues. Among the nanoemulsions, 1-O-decylglycerol stabilized system showed significantly higher tissue levels and availability of CBZ. Particularly for this system 2.37 times higher brain availability and a brain/serum concentration ratio of 3.0 at 30 min is an important finding. This indicates the brain targeting potential. A systematic formulation development of CBZ nanoemulsions employing 1-O-alkylglycerols might pave way to achieve selective brain delivery of this important antiepileptic drug.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbamazepine
/
Nanotechnology
/
Emulsions
/
Glycerol
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
J Drug Target
Journal subject:
FARMACOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
India
Country of publication:
United kingdom