Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.

Ishizuka, Ken; Usui, Isao; Kanatani, Yukiko; Bukhari, Agussalim; He, Jianying; Fujisaka, Shiho; Yamazaki, Yu; Suzuki, Hikari; Hiratani, Kazuyuki; Ishiki, Manabu; Iwata, Minoru; Urakaze, Masaharu; Haruta, Tetsuro; Kobayashi, Masashi

Ishizuka, Ken; Usui, Isao; Kanatani, Yukiko; Bukhari, Agussalim; He, Jianying; Fujisaka, Shiho; Yamazaki, Yu; Suzuki, Hikari; Hiratani, Kazuyuki; Ishiki, Manabu; Iwata, Minoru; Urakaze, Masaharu; Haruta, Tetsuro; Kobayashi, Masashi.

Affiliation

Ishizuka K; The First Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Endocrinology ; 148(6): 2994-3003, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17379643

Subject(s)

Adipocytes/drug effects; Insulin Resistance; Phosphoproteins/metabolism; Suppressor of Cytokine Signaling Proteins/metabolism; Tumor Necrosis Factor-alpha/pharmacology; 3T3-L1 Cells; Adipocytes/metabolism; Animals; Insulin/pharmacology; Insulin Receptor Substrate Proteins; Interleukin-6/metabolism; Mice; Phosphorylation; Protein Kinases/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction/drug effects; Suppressor of Cytokine Signaling 3 Protein; Time

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Insulin Resistance / Tumor Necrosis Factor-alpha / Adipocytes / Suppressor of Cytokine Signaling Proteins Type of study: Etiology_studies Limits: Animals Language: En Journal: Endocrinology Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United States

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