Your browser doesn't support javascript.
loading
2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.
Li, James J; Wang, Haixia; Tino, Joseph A; Robl, Jeffrey A; Herpin, Timothy F; Lawrence, R Michael; Biller, Scott; Jamil, Haris; Ponticiello, Randy; Chen, Luping; Chu, Ching-hsuen; Flynn, Neil; Cheng, Dong; Zhao, Rulin; Chen, Bangchi; Schnur, Dora; Obermeier, Mary T; Sasseville, Vito; Padmanabha, Ramesh; Pike, Kristen; Harrity, Thomas.
Affiliation
  • Li JJ; Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. James.Li@bms.com
Bioorg Med Chem Lett ; 17(11): 3208-11, 2007 Jun 01.
Article in En | MEDLINE | ID: mdl-17383874
ABSTRACT
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC(50)=0.13 microM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.
Subject(s)
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: ATP Citrate (pro-S)-Lyase / Sulfonamides / Benzene / Anti-Obesity Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: United States
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: ATP Citrate (pro-S)-Lyase / Sulfonamides / Benzene / Anti-Obesity Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: United States