Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists.
Acta Physiol (Oxf)
; 190(3): 209-19, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17394567
ABSTRACT
AIM:
Membrane fatty acid transporters can modulate the balance between fatty acid uptake and subsequent storage and/or oxidation in muscle tissue. As such, skeletal muscle fatty acid transporter protein expression could play an important role in the etiology of insulin resistance and/or type 2 diabetes.METHODS:
In the present study, fatty acid translocase (FAT/CD36), plasma membrane-bound fatty acid-binding protein (FABPpm) and fatty acid transport protein 1 (FATP1) mRNA and protein expression were assessed in muscle tissue obtained from 10 sedentary, overweight type 2 diabetes patients (60 +/- 2 years), 10 sedentary, weight-matched normoglycemic controls (60 +/- 2 years) and 10 age-matched, endurance trained cyclists (57 +/- 1 years).RESULTS:
Both FAT/CD36 and FATP1 mRNA and protein expression did not differ between groups. In contrast, FABPpm mRNA and protein expression were approx. 30-40% higher in the trained men compared with the diabetes patients (P < 0.01) and sedentary controls (P < 0.05).CONCLUSIONS:
Skeletal muscle FAT/CD36, FABPpm and FATP1 mRNA and protein expression are not up- or downregulated in a sedentary and/or insulin resistant state. In contrast, FABPpm expression is upregulated in the endurance trained state and likely instrumental to allow greater fatty acid oxidation rates.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Physical Endurance
/
Gene Expression Regulation
/
Muscle, Skeletal
/
Diabetes Mellitus, Type 2
/
Overweight
/
Fatty Acid Transport Proteins
Type of study:
Observational_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Physiol (Oxf)
Journal subject:
FISIOLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Netherlands