Signals from chloroplasts converge to regulate nuclear gene expression.
Science
; 316(5825): 715-9, 2007 May 04.
Article
in En
| MEDLINE
| ID: mdl-17395793
ABSTRACT
Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in Arabidopsis are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Cell Nucleus
/
Chloroplasts
/
Arabidopsis
/
Gene Expression Regulation, Plant
/
Arabidopsis Proteins
/
DNA-Binding Proteins
Type of study:
Prognostic_studies
Language:
En
Journal:
Science
Year:
2007
Document type:
Article
Affiliation country:
United States