Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.

Higuchi, Robert I; Arienti, Kristen L; López, Francisco J; Mani, Neelakhanda S; Mais, Dale E; Caferro, Thomas R; Long, Yun Oliver; Jones, Todd K; Edwards, James P; Zhi, Lin; Schrader, William T; Negro-Vilar, Andrés; Marschke, Keith B

Higuchi, Robert I; Arienti, Kristen L; López, Francisco J; Mani, Neelakhanda S; Mais, Dale E; Caferro, Thomas R; Long, Yun Oliver; Jones, Todd K; Edwards, James P; Zhi, Lin; Schrader, William T; Negro-Vilar, Andrés; Marschke, Keith B.

Affiliation

Higuchi RI; Discovery Research, Ligand Pharmaceuticals, Inc., 10275 Science Center Drive, San Diego, California 92121, USA. rhiguchi@ligand.com

J Med Chem ; 50(10): 2486-96, 2007 May 17.

Article in En | MEDLINE | ID: mdl-17439112

Subject(s)

Oxazines/chemical synthesis; Quinolones/chemical synthesis; Receptors, Androgen/drug effects; Anabolic Agents/chemical synthesis; Anabolic Agents/chemistry; Anabolic Agents/pharmacology; Androgens; Animals; Binding, Competitive; Cell Line, Tumor; Humans; Male; Muscle, Skeletal/anatomy & histology; Muscle, Skeletal/drug effects; Organ Size/drug effects; Oxazines/chemistry; Oxazines/pharmacology; Prostate/anatomy & histology; Prostate/drug effects; Quinolones/chemistry; Quinolones/pharmacology; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Transcriptional Activation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Receptors, Androgen / Quinolones Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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