In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.

Dixit, Vaishali; Hariparsad, Niresh; Desai, Pankaj; Unadkat, Jashvant D

Dixit, Vaishali; Hariparsad, Niresh; Desai, Pankaj; Unadkat, Jashvant D.

Affiliation

Dixit V; Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

Biopharm Drug Dispos ; 28(5): 257-62, 2007 Jul.

Article in En | MEDLINE | ID: mdl-17443647

Subject(s)

Chromatography, Liquid/methods; Cytochrome P-450 Enzyme System/metabolism; Mass Spectrometry/methods; Pharmaceutical Preparations/metabolism; Biological Assay/methods; Cells, Cultured; Cytochrome P-450 Enzyme System/analysis; Hepatocytes/cytology; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Isoenzymes/analysis; Isoenzymes/metabolism; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Pharmaceutical Preparations/administration & dosage; Reproducibility of Results; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Mass Spectrometry / Pharmaceutical Preparations / Chromatography, Liquid / Cytochrome P-450 Enzyme System Limits: Humans Language: En Journal: Biopharm Drug Dispos Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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