Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis.

Ochi, Nobuo; Matsuo, Yoichi; Sawai, Hirozumi; Yasuda, Akira; Takahashi, Hiroki; Sato, Mikinori; Funahashi, Hitoshi; Okada, Yuji; Manabe, Tadao

Ochi, Nobuo; Matsuo, Yoichi; Sawai, Hirozumi; Yasuda, Akira; Takahashi, Hiroki; Sato, Mikinori; Funahashi, Hitoshi; Okada, Yuji; Manabe, Tadao.

Affiliation

Ochi N; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan. nochi@med.nagoya-cu.ac.jp

Pancreas ; 34(4): 444-51, 2007 May.

Article in En | MEDLINE | ID: mdl-17446844

Subject(s)

Cell Movement; Endothelial Cells/metabolism; Lymphangiogenesis; Lymphatic Vessels/metabolism; Pancreatic Neoplasms/metabolism; Paracrine Communication; Vascular Endothelial Growth Factor C/metabolism; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation; Coculture Techniques; Culture Media, Conditioned/metabolism; Dose-Response Relationship, Drug; Endothelial Cells/drug effects; Endothelial Cells/pathology; Fibroblasts/metabolism; Humans; Lymphangiogenesis/drug effects; Lymphatic Metastasis; Lymphatic Vessels/drug effects; Lymphatic Vessels/pathology; Lymphatic Vessels/physiopathology; Pancreatic Neoplasms/pathology; Pancreatic Neoplasms/physiopathology; RNA, Messenger/metabolism; Recombinant Fusion Proteins/pharmacology; Recombinant Proteins/pharmacology; Vascular Endothelial Growth Factor C/genetics; Vascular Endothelial Growth Factor C/pharmacology; Vascular Endothelial Growth Factor Receptor-3/genetics; Vascular Endothelial Growth Factor Receptor-3/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Cell Movement / Paracrine Communication / Endothelial Cells / Lymphatic Vessels / Vascular Endothelial Growth Factor C / Lymphangiogenesis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Pancreas Journal subject: GASTROENTEROLOGIA Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United States

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