The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.

Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi; Almeida, Claudia G; Greengard, Paul; Nyberg, Fred; Gouras, Gunnar K; Lannfelt, Lars; Nilsson, Lars N G

Sahlin, Charlotte; Lord, Anna; Magnusson, Kristina; Englund, Hillevi; Almeida, Claudia G; Greengard, Paul; Nyberg, Fred; Gouras, Gunnar K; Lannfelt, Lars; Nilsson, Lars N G.

Affiliation

Sahlin C; Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. charlotte.sahlin@pubcare.uu.se

J Neurochem ; 101(3): 854-62, 2007 May.

Article in En | MEDLINE | ID: mdl-17448150

Subject(s)

Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Peptides/genetics; Mutation/physiology; Cell Line, Tumor; Humans; Mutagenesis, Site-Directed/methods; Neuroblastoma; Protein Structure, Tertiary; Transfection/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Amyloid Precursor Protein Secretases / Mutation Limits: Humans Language: En Journal: J Neurochem Year: 2007 Document type: Article Affiliation country: Sweden Country of publication: United kingdom

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