Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo.

O'Shaughnessy, Matthew J; Chen, Zong-Ming; Gramaglia, Irene; Taylor, Patricia A; Panoskaltsis-Mortari, Angela; Vogtenhuber, Christine; Palmer, Ed; Grader-Beck, Thomas; Boussiotis, Vassiliki A; Blazar, Bruce R

O'Shaughnessy, Matthew J; Chen, Zong-Ming; Gramaglia, Irene; Taylor, Patricia A; Panoskaltsis-Mortari, Angela; Vogtenhuber, Christine; Palmer, Ed; Grader-Beck, Thomas; Boussiotis, Vassiliki A; Blazar, Bruce R.

Affiliation

O'Shaughnessy MJ; University of Minnesota Cancer Center, Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, Minnesota 55455, USA.

Biol Blood Marrow Transplant ; 13(5): 530-42, 2007 May.

Article in En | MEDLINE | ID: mdl-17448912

Subject(s)

CD4-Positive T-Lymphocytes/transplantation; Cyclic AMP/metabolism; Graft vs Host Disease/prevention & control; Phosphodiesterase Inhibitors/pharmacology; 1-Methyl-3-isobutylxanthine/pharmacology; Animals; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; Cell Transplantation; Cyclic AMP/analogs & derivatives; Graft vs Host Disease/immunology; Immune Tolerance; Isoantibodies/analysis; Isoantibodies/immunology; Lymphocyte Culture Test, Mixed/methods; Mice; Mice, Transgenic; Survival Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / CD4-Positive T-Lymphocytes / Cyclic AMP / Graft vs Host Disease Limits: Animals Language: En Journal: Biol Blood Marrow Transplant Journal subject: HEMATOLOGIA / TRANSPLANTE Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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