Interstitial flow and its effects in soft tissues.
Annu Rev Biomed Eng
; 9: 229-56, 2007.
Article
in En
| MEDLINE
| ID: mdl-17459001
ABSTRACT
Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of tissues. To investigate these roles and exploit them for tissue engineering or to overcome barriers to drug delivery, a comprehensive consideration of the interstitial space and how it controls and affects such processes is critical. Here we attempt to review the many physical and mathematical correlations that describe fluid and mass transport in the tissue interstitium; the factors that control and affect them; and the importance of interstitial transport on cell biology, tissue morphogenesis, and tissue engineering. Finally, we end with some discussion of interstitial transport issues in drug delivery, cell mechanobiology, and cell homing toward draining lymphatics.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Connective Tissue
/
Tissue Engineering
/
Mechanotransduction, Cellular
/
Extracellular Fluid
/
Extracellular Matrix
/
Models, Biological
Type of study:
Prognostic_studies
Language:
En
Journal:
Annu Rev Biomed Eng
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2007
Document type:
Article
Affiliation country:
Switzerland