Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.

Franke, Lutz; Schwarz, Oliver; Müller-Kuhrt, Lutz; Hoernig, Christina; Fischer, Lutz; George, Sven; Tanrikulu, Yusuf; Schneider, Petra; Werz, Oliver; Steinhilber, Dieter; Schneider, Gisbert

Franke, Lutz; Schwarz, Oliver; Müller-Kuhrt, Lutz; Hoernig, Christina; Fischer, Lutz; George, Sven; Tanrikulu, Yusuf; Schneider, Petra; Werz, Oliver; Steinhilber, Dieter; Schneider, Gisbert.

Affiliation

Franke L; Institut für Organische Chemie und Chemische Biologie/ZAFES, Johann Wolfgang Goethe-Universität, Siesmayerstrasse 70, D-60323 Frankfurt am Main, Germany.

J Med Chem ; 50(11): 2640-6, 2007 May 31.

Article in En | MEDLINE | ID: mdl-17461565

Subject(s)

Arachidonate 5-Lipoxygenase/chemistry; Biological Products/chemistry; Lipoxygenase Inhibitors; Adult; Biological Products/pharmacology; Cell-Free System; Databases, Factual; Humans; In Vitro Techniques; Models, Molecular; Neutrophils/drug effects; Neutrophils/enzymology; Pyridines/chemistry; Pyridines/pharmacology; Structure-Activity Relationship; Tetrahydronaphthalenes/chemistry; Tetrahydronaphthalenes/pharmacology; Thiazoles/chemistry; Thiazoles/pharmacology; Thiophenes/chemistry; Thiophenes/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Arachidonate 5-Lipoxygenase / Lipoxygenase Inhibitors Type of study: Diagnostic_studies / Screening_studies Limits: Adult / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: Germany Country of publication: United States

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