Synthesis of isomeric, oxathiolone fused chalcones, and comparison of their activity toward various microorganisms and human cancer cells line.
Chem Pharm Bull (Tokyo)
; 55(5): 817-20, 2007 May.
Article
in En
| MEDLINE
| ID: mdl-17473478
ABSTRACT
Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Proteus vulgaris, antifungal activity against Candida albicans, and tuberculostatic activity against Mycobacterium tuberculosis H(37)Rv and Mycobacterium kansasii strains.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bridged Bicyclo Compounds, Heterocyclic
/
Chalcones
/
Anti-Infective Agents
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2007
Document type:
Article
Affiliation country:
Poland