Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.

Tooker, Patricia; Yen, Wan-Ching; Ng, Shi-Chung; Negro-Vilar, Andrès; Hermann, Thomas W

Tooker, Patricia; Yen, Wan-Ching; Ng, Shi-Chung; Negro-Vilar, Andrès; Hermann, Thomas W.

Affiliation

Tooker P; Department of Molecular Oncology, Ligand Pharmaceuticals, Inc., San Diego, California 92121, USA.

Cancer Res ; 67(9): 4425-33, 2007 May 01.

Article in En | MEDLINE | ID: mdl-17483357

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Deoxycytidine/analogs & derivatives; Lung Neoplasms/drug therapy; Retinoid X Receptors/agonists; Tetrahydronaphthalenes/pharmacology; Animals; Bexarotene; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/pathology; Cell Growth Processes/drug effects; Cell Line, Tumor; Deoxycytidine/administration & dosage; Deoxycytidine/pharmacology; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Amplification/drug effects; Humans; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mice; Mice, Nude; Tetrahydronaphthalenes/administration & dosage; Xenograft Model Antitumor Assays; Gemcitabine

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Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydronaphthalenes / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Non-Small-Cell Lung / Deoxycytidine / Retinoid X Receptors / Lung Neoplasms Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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