Comparison of efficacies of a dipeptidyl peptidase IV inhibitor and alpha-glucosidase inhibitors in oral carbohydrate and meal tolerance tests and the effects of their combination in mice.

Yamazaki, Kazuto; Inoue, Takashi; Yasuda, Nobuyuki; Sato, Yoshiaki; Nagakura, Tadashi; Takenaka, Osamu; Clark, Richard; Saeki, Takao; Tanaka, Isao

Yamazaki, Kazuto; Inoue, Takashi; Yasuda, Nobuyuki; Sato, Yoshiaki; Nagakura, Tadashi; Takenaka, Osamu; Clark, Richard; Saeki, Takao; Tanaka, Isao.

Affiliation

Yamazaki K; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan. k5-yamazaki@hhc.eisai.co.jp

J Pharmacol Sci ; 104(1): 29-38, 2007 May.

Article in En | MEDLINE | ID: mdl-17485917

Subject(s)

Dipeptidyl-Peptidase IV Inhibitors; Enzyme Inhibitors/pharmacokinetics; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents/pharmacokinetics; Acarbose/administration & dosage; Acarbose/pharmacokinetics; Acarbose/therapeutic use; Administration, Oral; Animals; Area Under Curve; Blood Glucose/metabolism; Carbohydrate Metabolism/drug effects; Diabetes Mellitus, Type 2/drug therapy; Dietary Sucrose/administration & dosage; Dietary Sucrose/metabolism; Drug Therapy, Combination; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/therapeutic use; Food, Formulated; Glucagon-Like Peptide 1/blood; Glucose Tolerance Test/methods; Hyperglycemia/blood; Hyperglycemia/prevention & control; Hypoglycemic Agents/administration & dosage; Hypoglycemic Agents/therapeutic use; Imidazoles/administration & dosage; Imidazoles/pharmacokinetics; Imidazoles/therapeutic use; Injections, Intravenous; Inositol/administration & dosage; Inositol/analogs & derivatives; Inositol/pharmacokinetics; Inositol/therapeutic use; Insulin/blood; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Pyridazines/administration & dosage; Pyridazines/pharmacokinetics; Pyridazines/therapeutic use; Tosyl Compounds/administration & dosage; Tosyl Compounds/pharmacokinetics; Tosyl Compounds/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Dipeptidyl-Peptidase IV Inhibitors / Glycoside Hydrolase Inhibitors / Hypoglycemic Agents Type of study: Prognostic_studies Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2007 Document type: Article Affiliation country: Japan Country of publication: Japan

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