In vitro and in vivo comparison of creams containing dithranol 0.5%.
Pharm Weekbl Sci
; 13(5): 210-4, 1991 Oct 18.
Article
in En
| MEDLINE
| ID: mdl-1749710
ABSTRACT
In an in vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predicting in vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anthralin
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pharm Weekbl Sci
Year:
1991
Document type:
Article
Affiliation country:
Netherlands