A general and efficient 2-amination of pyridines and quinolines.
J Org Chem
; 72(12): 4554-7, 2007 Jun 08.
Article
in En
| MEDLINE
| ID: mdl-17500567
ABSTRACT
Pyridine N-oxides were converted to 2-aminopyridines in a one-pot fashion using Ts2O-t-BuNH2 followed by in situ deprotection with TFA. The amination proceeded in high yields, excellent 2-/4-selectivity, and with good functional group compatibility. 2-Amino (iso)quinolines were also obtained in the same manner. Combined with the simple oxidation of pyridines to pyridine N-oxides, this method provides a general and efficient way for amination of 2-unsubstituted pyridines.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridines
/
Quinolines
/
Aminopyridines
/
Aminoquinolines
Language:
En
Journal:
J Org Chem
Year:
2007
Document type:
Article
Affiliation country:
United States