Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program.

Dhodapkar, Kavita M; Banerjee, Devi; Connolly, John; Kukreja, Anjli; Matayeva, Elyana; Veri, Maria Concetta; Ravetch, Jeffrey V; Steinman, Ralph M; Dhodapkar, Madhav V

Dhodapkar, Kavita M; Banerjee, Devi; Connolly, John; Kukreja, Anjli; Matayeva, Elyana; Veri, Maria Concetta; Ravetch, Jeffrey V; Steinman, Ralph M; Dhodapkar, Madhav V.

Affiliation

Dhodapkar KM; Lab of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA. dhodapk@rockefeller.edu

J Exp Med ; 204(6): 1359-69, 2007 Jun 11.

Article in En | MEDLINE | ID: mdl-17502666

Subject(s)

Dendritic Cells/immunology; Gene Expression Regulation/immunology; Interferon Type I/immunology; Monocytes/immunology; Receptors, IgG/antagonists & inhibitors; Signal Transduction/immunology; Antibodies/pharmacology; Blotting, Western; Cytokines/metabolism; Dendritic Cells/metabolism; Flow Cytometry; Gene Expression Profiling; Humans; Interferon Type I/metabolism; Monocytes/metabolism; Oligonucleotide Array Sequence Analysis; RNA Interference; STAT1 Transcription Factor/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Monocytes / Signal Transduction / Interferon Type I / Gene Expression Regulation / Receptors, IgG Limits: Humans Language: En Journal: J Exp Med Year: 2007 Document type: Article Affiliation country: United States

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