Global gene expression in Ha-ras and B-raf mutated mouse liver tumors.
Int J Cancer
; 121(6): 1382-5, 2007 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-17514646
ABSTRACT
Chemically-induced mouse liver tumors harbor mutations in different oncogenes. About 50% of tumors contain activating mutations in the Ha-ras gene contain and about 20% of tumors show point mutations in the B-raf oncogene. We have investigated the gene expression profiles in tumors of the 2 genotypes by microarray analysis. In total, approximately 500 genes or expressed sequences were aberrantly expressed in tumors relative to normal liver tissue. Around two/thirds of them were significantly altered in both Ha-ras and B-raf mutated liver tumors, and most of the remaining genes showed at least qualitatively comparable changes in both tumor types. Several functional clusters were hypothesized in tumors of the 2 genotypes which involve alterations in a battery of genes encoding enzymes of lipid metabolism. The similarity in the patterns of global gene expression of Ha-ras and B-raf mutated liver tumors suggests that mutational activation of the 2 oncogenes results in activation of a common set of transcriptional regulators.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes, ras
/
Proto-Oncogene Proteins B-raf
/
Liver Neoplasms, Experimental
Limits:
Animals
Language:
En
Journal:
Int J Cancer
Year:
2007
Document type:
Article
Affiliation country:
Germany