A new bioluminescent cellular assay to measure the transcriptional effects of chemicals that modulate the alpha-1 thyroid hormone receptor.

Jugan, M L; Lévy-Bimbot, M; Pomérance, M; Tamisier-Karolak, S; Blondeau, J P; Lévi, Y

Jugan, M L; Lévy-Bimbot, M; Pomérance, M; Tamisier-Karolak, S; Blondeau, J P; Lévi, Y.

Affiliation

Jugan ML; Univ Paris-Sud, Faculté de Pharmacie, Laboratoire Santé Publique-Environnement, F-92296 Châtenay-Malabry, France.

Toxicol In Vitro ; 21(6): 1197-205, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17532181

Subject(s)

Biological Assay; Endocrine Disruptors/toxicity; Thyroid Hormone Receptors alpha/metabolism; Animals; Environmental Pollutants/toxicity; Flame Retardants/toxicity; Genes, Reporter; Luciferases/genetics; Luciferases/metabolism; Luminescence; PC12 Cells; Phenols/toxicity; Polybrominated Biphenyls/toxicity; Polychlorinated Biphenyls/toxicity; Rats; Thyroid Hormone Receptors alpha/genetics; Transcription, Genetic/drug effects; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Biological Assay / Thyroid Hormone Receptors alpha / Endocrine Disruptors Limits: Animals Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2007 Document type: Article Affiliation country: France Country of publication: United kingdom

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