C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice.

Zwijnenburg, Petra J G; van der Poll, Tom; Florquin, Sandrine; Polfliet, Machteld M J; van den Berg, Timo K; Dijkstra, Christine D; Roord, John J; Hack, C Erik; van Furth, A Marceline

Zwijnenburg, Petra J G; van der Poll, Tom; Florquin, Sandrine; Polfliet, Machteld M J; van den Berg, Timo K; Dijkstra, Christine D; Roord, John J; Hack, C Erik; van Furth, A Marceline.

Affiliation

Zwijnenburg PJ; Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. p.zwijnenburg@vumc.nl

J Infect Dis ; 196(1): 115-23, 2007 Jul 01.

Article in En | MEDLINE | ID: mdl-17538891

Subject(s)

Complement C1 Inhibitor Protein/pharmacology; Complement C1/antagonists & inhibitors; Meningitis, Pneumococcal/immunology; Meningitis, Pneumococcal/pathology; Animals; Brain/immunology; Brain/pathology; Brain Chemistry; Cerebrospinal Fluid/microbiology; Chemokines/analysis; Colony Count, Microbial; Complement Activation; Complement C1 Inhibitor Protein/administration & dosage; Complement Pathway, Classical; Cytokines/analysis; Disease Models, Animal; Humans; Macrophage-1 Antigen/biosynthesis; Male; Meninges/pathology; Meningitis, Pneumococcal/microbiology; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Streptococcus pneumoniae/isolation & purification

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Collection: 01-internacional Database: MEDLINE Main subject: Complement C1 / Complement C1 Inhibitor Protein / Meningitis, Pneumococcal Limits: Animals / Humans / Male Language: En Journal: J Infect Dis Year: 2007 Document type: Article Affiliation country: Netherlands Country of publication: United States

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