[Chronopharmacokinetics of dexamethasone in young subjects]. / Chronopharmacocinétique de la dexaméthasone chez le sujet jeune.
Therapie
; 46(5): 405-7, 1991.
Article
in Fr
| MEDLINE
| ID: mdl-1754989
ABSTRACT
Dexamethasone chronopharmacokinetics was studied in six young subjects 20 to 30 years old. The randomized cross-over study consisted of evening (11.00 p.m.) or morning (08.00 a.m.) dose separated by a period of one week. After the evening administration of the drug, only Tmax (1.77 +/- 0.74 à 11.00 p.m. and 0.99 +/- 0.64 à 08.00 a.m.) and Cmax/Tmax were higher than those determined at 08.00 a.m. This difference might be related to a cyclic variation of the absorption phase of dexamethasone. Thus, in our study, the time of administration has only a weak effect on the pharmacokinetics of dexamethasone.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dexamethasone
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Fr
Journal:
Therapie
Year:
1991
Document type:
Article