[Effects of Salvia miltiorrhiza on Chlamydia trachomatis mice of salpingitis].
Zhongguo Zhong Yao Za Zhi
; 32(6): 523-5, 2007 Mar.
Article
in Zh
| MEDLINE
| ID: mdl-17552161
ABSTRACT
OBJECTIVE:
To study the effects of Salvia miltiorrhiza on treatment of Chlamydia trachomatis salpingitis (CTS) and fibrosis.METHOD:
A mouse model for CTS was estahlished in C3H/He by intravaginal inoculation. after 3 weeks mice were randomly divided into 3 groups. Only Azithromyxin was given orally, Azithromyxin and early S. miltiorrhiza given, or Azithromyxin and later S. miltiorrhiza given. After 10 weeks, observe the change of oviduct of mice, observe the histopathologic change and analysis collagen histochemical index.RESULT:
3 Treatment groups induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than those of no treatment given (P < 0.05). Early S. miltiorrhiza given group induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than only Azithromyxin group or later S. miltiorrhiza given group (P <0.05).CONCLUSION:
When we treat CTS genital infection with Azithromyxin, if we can give S. miltiorrhiza treatment as early as possible, it may decrease tubal occlusion and hydrosalpinx. significantly inhibit fibrosis maybe one of its pharmacologic mechanismin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salpingitis
/
Drugs, Chinese Herbal
/
Chlamydia Infections
/
Salvia miltiorrhiza
Type of study:
Etiology_studies
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Journal subject:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Year:
2007
Document type:
Article
Affiliation country:
China