Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Furuhashi, Masato; Tuncman, Gürol; Görgün, Cem Z; Makowski, Liza; Atsumi, Genichi; Vaillancourt, Eric; Kono, Keita; Babaev, Vladimir R; Fazio, Sergio; Linton, MacRae F; Sulsky, Richard; Robl, Jeffrey A; Parker, Rex A; Hotamisligil, Gökhan S

Furuhashi, Masato; Tuncman, Gürol; Görgün, Cem Z; Makowski, Liza; Atsumi, Genichi; Vaillancourt, Eric; Kono, Keita; Babaev, Vladimir R; Fazio, Sergio; Linton, MacRae F; Sulsky, Richard; Robl, Jeffrey A; Parker, Rex A; Hotamisligil, Gökhan S.

Affiliation

Furuhashi M; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Nature ; 447(7147): 959-65, 2007 Jun 21.

Article in En | MEDLINE | ID: mdl-17554340

Subject(s)

Atherosclerosis/drug therapy; Diabetes Mellitus/drug therapy; Fatty Acid-Binding Proteins/antagonists & inhibitors; Adipocytes/drug effects; Adipocytes/metabolism; Adipose Tissue/cytology; Adipose Tissue/drug effects; Adipose Tissue/metabolism; Animals; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/genetics; Atherosclerosis/metabolism; Biphenyl Compounds/metabolism; Cell Line; Cholesterol/metabolism; Diabetes Mellitus/genetics; Diabetes Mellitus/metabolism; Fatty Acid-Binding Proteins/metabolism; Humans; Inflammation/metabolism; Liver/drug effects; Liver/metabolism; Macrophages/drug effects; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Biological; Obesity/genetics; Obesity/metabolism; Pyrazoles/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus / Atherosclerosis / Fatty Acid-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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