Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.

Clark, Michelle K; Scott, Sarah A; Wojtkowiak, Jonathan; Chirco, Rosemarie; Mathieu, Patricia; Reiners, John J; Mattingly, Raymond R; Borch, Richard F; Gibbs, Richard A

Clark, Michelle K; Scott, Sarah A; Wojtkowiak, Jonathan; Chirco, Rosemarie; Mathieu, Patricia; Reiners, John J; Mattingly, Raymond R; Borch, Richard F; Gibbs, Richard A.

Affiliation

Clark MK; Medicinal Chemistry and Molecular Pharmacology and Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.

J Med Chem ; 50(14): 3274-82, 2007 Jul 12.

Article in En | MEDLINE | ID: mdl-17555307

Subject(s)

Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Farnesyltranstransferase/antagonists & inhibitors; Polyisoprenyl Phosphates/chemical synthesis; Polyisoprenyl Phosphates/pharmacology; Prodrugs/pharmacology; Cell Line; Cell Proliferation/drug effects; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Prodrugs/chemical synthesis; Spectrometry, Mass, Electrospray Ionization

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Collection: 01-internacional Database: MEDLINE Main subject: Polyisoprenyl Phosphates / Prodrugs / Enzyme Inhibitors / Farnesyltranstransferase Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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