Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.

Kallen, Joerg; Lattmann, Rene; Beerli, Rene; Blechschmidt, Anke; Blommers, Marcel J J; Geiser, Martin; Ottl, Johannes; Schlaeppi, Jean-Marc; Strauss, Andre; Fournier, Brigitte

Kallen, Joerg; Lattmann, Rene; Beerli, Rene; Blechschmidt, Anke; Blommers, Marcel J J; Geiser, Martin; Ottl, Johannes; Schlaeppi, Jean-Marc; Strauss, Andre; Fournier, Brigitte.

Affiliation

Kallen J; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. Joerg.kallen@novartis.com

J Biol Chem ; 282(32): 23231-9, 2007 Aug 10.

Article in En | MEDLINE | ID: mdl-17556356

Subject(s)

Receptors, Estrogen/chemistry; Crystallography, X-Ray; Drug Design; Estrogen Receptor alpha/chemistry; Humans; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Nitrogen/chemistry; Protein Binding; Protein Conformation; Protein Structure, Tertiary; ERRalpha Estrogen-Related Receptor

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Estrogen Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2007 Document type: Article Affiliation country: Switzerland Country of publication: United States

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