Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta.

Akeboshi, Hiromi; Chiba, Yasunori; Kasahara, Yoshiko; Takashiba, Minako; Takaoka, Yuki; Ohsawa, Mai; Tajima, Youichi; Kawashima, Ikuo; Tsuji, Daisuke; Itoh, Kohji; Sakuraba, Hitoshi; Jigami, Yoshifumi

Akeboshi, Hiromi; Chiba, Yasunori; Kasahara, Yoshiko; Takashiba, Minako; Takaoka, Yuki; Ohsawa, Mai; Tajima, Youichi; Kawashima, Ikuo; Tsuji, Daisuke; Itoh, Kohji; Sakuraba, Hitoshi; Jigami, Yoshifumi.

Affiliation

Akeboshi H; Research Center for Glycoscience, AIST Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan.

Appl Environ Microbiol ; 73(15): 4805-12, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17557860

Subject(s)

Recombinant Proteins/biosynthesis; Saccharomycetales/enzymology; Sandhoff Disease/enzymology; Tay-Sachs Disease/enzymology; beta-N-Acetylhexosaminidases/biosynthesis; Amino Acid Sequence; Biotechnology/methods; Cells, Cultured; Fibroblasts/enzymology; Hexosaminidase A; Hexosaminidase B; Humans; Molecular Sequence Data; Recombinant Proteins/genetics; Recombinant Proteins/therapeutic use; Saccharomycetales/genetics; Sandhoff Disease/therapy; Tay-Sachs Disease/therapy; beta-N-Acetylhexosaminidases/genetics; beta-N-Acetylhexosaminidases/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sandhoff Disease / Tay-Sachs Disease / Beta-N-Acetylhexosaminidases / Recombinant Proteins / Saccharomycetales Type of study: Evaluation_studies Limits: Humans Language: En Journal: Appl Environ Microbiol Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United States

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