Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker.
J Mater Sci Mater Med
; 18(10): 2045-51, 2007 Oct.
Article
in En
| MEDLINE
| ID: mdl-17558474
ABSTRACT
Hydroxyapatite [HAp]/Gelatin [GEL] nanocomposite was prepared at 37 and 48 degrees C through coprecipitation process. The HAp/GEL nanocomposite slurries were cross-linked by imide-based zero-length cross-linking agent such as N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemical bond formation and microstructure in HAp/GEL nanocomposite was investigated as a function of cross-linking agents and temperature. The single addition of EDC into the composite slurries resulted in a tougher microstructure in both samples prepared at 37 and 48 degrees C. However, in the case of the simultaneous addition of EDC and NHS the sample prepared at 48 degrees C showed a coarse microstructure. These results were consistent with the fact that the chemical reactivity of NHS is degraded at 48 degrees C whereas the reactivity of EDC increases up to 80 degrees C.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Durapatite
/
Cross-Linking Reagents
/
Nanocomposites
/
Gelatin
/
Imides
Type of study:
Evaluation_studies
Language:
En
Journal:
J Mater Sci Mater Med
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2007
Document type:
Article