Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

Rahn, E J; Makriyannis, A; Hohmann, A G

Rahn, E J; Makriyannis, A; Hohmann, A G.

Affiliation

Rahn EJ; Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA 30602-3013, USA.

Br J Pharmacol ; 152(5): 765-77, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17572696

Subject(s)

Neuralgia/prevention & control; Receptor, Cannabinoid, CB1/physiology; Receptor, Cannabinoid, CB2/physiology; Vincristine/toxicity; Animals; Benzoxazines/pharmacology; Body Weight/drug effects; Camphanes/pharmacology; Cannabinoids/pharmacology; Catalepsy/chemically induced; Catalepsy/prevention & control; Dose-Response Relationship, Drug; Hindlimb; Hyperesthesia/chemically induced; Hyperesthesia/prevention & control; Injections, Intraperitoneal; Injections, Spinal; Male; Morphine/pharmacology; Morpholines/pharmacology; Naphthalenes/pharmacology; Neuralgia/chemically induced; Pain Measurement/instrumentation; Pain Measurement/methods; Pain Threshold/drug effects; Physical Stimulation; Piperidines/pharmacology; Pyrazoles/pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1/agonists; Receptor, Cannabinoid, CB2/agonists; Rimonabant; Thermosensing/physiology; Vincristine/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vincristine / Receptor, Cannabinoid, CB1 / Receptor, Cannabinoid, CB2 / Neuralgia Language: En Journal: Br J Pharmacol Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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