In vivo administration of doxazosin in rats highly decreases serum circulating levels of testosterone through a mechanism involving the testicular renin-angiotensin system.

de la Chica-Rodríguez, S; Cortés-Denia, P; Ramírez-Expósito, M J; de Saavedra, J M Arias; Sánchez-Agesta, R; Pérez, M del Cármen; Martínez-Martos, J M

de la Chica-Rodríguez, S; Cortés-Denia, P; Ramírez-Expósito, M J; de Saavedra, J M Arias; Sánchez-Agesta, R; Pérez, M del Cármen; Martínez-Martos, J M.

Affiliation

de la Chica-Rodríguez S; Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, Faculty of Experimental and Health Sciences, University of Jaén, Jaén, Spain.

Int J Androl ; 31(3): 364-70, 2008 Jun.

Article in En | MEDLINE | ID: mdl-17573849

Subject(s)

Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists/administration & dosage; Antihypertensive Agents/administration & dosage; Doxazosin/administration & dosage; Renin-Angiotensin System/drug effects; Testis/drug effects; Testosterone/blood; Aminopeptidases/metabolism; Animals; CD13 Antigens/metabolism; Down-Regulation; Glutamyl Aminopeptidase/metabolism; Injections, Subcutaneous; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1/metabolism; Testis/enzymology; Testis/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Renin-Angiotensin System / Testis / Testosterone / Doxazosin / Adrenergic alpha-Antagonists / Adrenergic alpha-1 Receptor Antagonists / Antihypertensive Agents Limits: Animals Language: En Journal: Int J Androl Year: 2008 Document type: Article Affiliation country: Spain Country of publication: United kingdom

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