Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Bioorg Med Chem Lett
; 17(16): 4531-7, 2007 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-17574411
ABSTRACT
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models and may be useful for the treatment of hypercholesterolemia and related lipid disorders.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
United States