Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Bioorg Med Chem Lett
; 17(16): 4538-44, 2007 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-17574412
ABSTRACT
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
United States