The immune response during a Strongyloides ratti infection of rats.
Parasite Immunol
; 29(7): 339-46, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17576363
ABSTRACT
A range of immune parameters was measured during a primary infection of Strongyloides ratti in its natural rat host. The immune parameters measured were interleukin-4 (IL-4) and interferon-gamma from both the spleen and mesenteric lymph node (MLN) cells; parasite-specific immunoglobulin G(1)(IgG(1)), IgG(2a) and IgG(2b) in serum and in intestinal tissue; parasite-specific IgG and total IgE in serum; parasite-specific and total IgA in intestinal tissue and rat mast cell protease II in intestinal tissue. Parasite-specific IgG(1), IgG(2a) and total IgE in serum and parasite-specific IgA and rat mast cell protease II in intestinal tissue all occurred at significantly greater concentrations in infected animals, compared with non-infected animals. Similarly, the production of IL-4 by MLN cells stimulated with parasitic female antigen or concanavalin A occurred at significantly greater concentrations in infected animals, compared with non-infected animals. In all, this suggests that there is a T-helper 2-type immune response during a primary S. ratti infection. These data also show the temporal changes in these components of the host immune response during a primary S. ratti infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Strongyloidiasis
/
Strongyloides ratti
/
Th2 Cells
Limits:
Animals
Language:
En
Journal:
Parasite Immunol
Year:
2007
Document type:
Article
Affiliation country:
United kingdom