Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.

Pepper, C; Lowe, H; Fegan, C; Thurieau, C; Thurston, D E; Hartley, J A; Delavault, P

Pepper, C; Lowe, H; Fegan, C; Thurieau, C; Thurston, D E; Hartley, J A; Delavault, P.

Affiliation

Pepper C; Department of Haematology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK. peppercj@cf.ac.uk

Br J Cancer ; 97(2): 253-9, 2007 Jul 16.

Article in En | MEDLINE | ID: mdl-17579621

Subject(s)

Antineoplastic Agents/pharmacology; Benzodiazepinones/pharmacology; Cross-Linking Reagents/pharmacology; DNA-Binding Proteins/antagonists & inhibitors; Endonucleases/antagonists & inhibitors; Leukemia, Lymphocytic, Chronic, B-Cell/enzymology; Pyrroles/pharmacology; Vidarabine/analogs & derivatives; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones/therapeutic use; DNA/drug effects; DNA/genetics; DNA Repair/drug effects; DNA-Binding Proteins/genetics; Drug Synergism; Endonucleases/genetics; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Male; Middle Aged; Pyrroles/therapeutic use; Transcription, Genetic/drug effects; Tumor Cells, Cultured; Vidarabine/pharmacology; Vidarabine/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Vidarabine / Benzodiazepinones / Leukemia, Lymphocytic, Chronic, B-Cell / Cross-Linking Reagents / DNA-Binding Proteins / Endonucleases / Antineoplastic Agents Limits: Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2007 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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