Mitochondrial oxidative stress causes hyperphosphorylation of tau.

Melov, Simon; Adlard, Paul A; Morten, Karl; Johnson, Felicity; Golden, Tamara R; Hinerfeld, Doug; Schilling, Birgit; Mavros, Christine; Masters, Colin L; Volitakis, Irene; Li, Qiao-Xin; Laughton, Katrina; Hubbard, Alan; Cherny, Robert A; Gibson, Brad; Bush, Ashley I

Melov, Simon; Adlard, Paul A; Morten, Karl; Johnson, Felicity; Golden, Tamara R; Hinerfeld, Doug; Schilling, Birgit; Mavros, Christine; Masters, Colin L; Volitakis, Irene; Li, Qiao-Xin; Laughton, Katrina; Hubbard, Alan; Cherny, Robert A; Gibson, Brad; Bush, Ashley I.

Affiliation

Melov S; Buck Institute for Age Research, Novato, California, United States of America. smelov@buckinstitute.org

PLoS One ; 2(6): e536, 2007 Jun 20.

Article in En | MEDLINE | ID: mdl-17579710

Subject(s)

Mitochondria/metabolism; Mitochondria/pathology; Oxidative Stress; Superoxide Dismutase/physiology; tau Proteins/metabolism; Animals; Antioxidants/pharmacology; Blotting, Western; Female; Immunoenzyme Techniques; Immunoprecipitation; Male; Metals/analysis; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation/drug effects; Plaque, Amyloid/chemistry; Reactive Oxygen Species; Spectrometry, Mass, Electrospray Ionization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Tau Proteins / Oxidative Stress / Mitochondria Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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