Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme.

Kassahun, Kelem; McIntosh, Ian; Cui, Donghui; Hreniuk, David; Merschman, Shelia; Lasseter, Kenneth; Azrolan, Neal; Iwamoto, Marian; Wagner, John A; Wenning, Larissa A

Kassahun, Kelem; McIntosh, Ian; Cui, Donghui; Hreniuk, David; Merschman, Shelia; Lasseter, Kenneth; Azrolan, Neal; Iwamoto, Marian; Wagner, John A; Wenning, Larissa A.

Affiliation

Kassahun K; Department of Drug Metabolism, WP75B-200, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA. kelem_kassahun@merck.com

Drug Metab Dispos ; 35(9): 1657-63, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17591678

Subject(s)

HIV Integrase Inhibitors/pharmacokinetics; HIV Integrase/drug effects; Organic Chemicals/pharmacokinetics; Adolescent; Adult; Animals; Chromatography, High Pressure Liquid; Feces/chemistry; Glucuronides/metabolism; Humans; In Vitro Techniques; Male; Microsomes, Liver/metabolism; Middle Aged; Oxidation-Reduction; Pyrrolidinones; Raltegravir Potassium; Rats; Rats, Sprague-Dawley

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Organic Chemicals / HIV Integrase Inhibitors / HIV Integrase Limits: Adolescent / Adult / Animals / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links