Roles of calmodulin and calmodulin-binding proteins in synaptic vesicle recycling during regulated exocytosis at submicromolar Ca2+ concentrations.
Neurosci Res
; 58(3): 226-33, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17601619
ABSTRACT
Calcium ion is required at various concentrations for vesicular recycling in the presynaptic terminal. Although calmodulin (CaM) is the most abundant Ca2+-binding protein and has a submicromolar affinity for Ca2+, it is not the Ca2+ sensor for vesicular fusion because this process requires Ca2+ concentrations above 1 microM. Several lines of evidence, however, suggest that CaM mediates the regulation of vesicular recycling by submicromolar Ca2+ via novel protein-protein interactions. In this review, we discuss recent findings on how CaM regulates synaptic vesicle recycling by controlling the SNARE mechanism, which is the molecular machinery that mediates exocytosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synaptic Vesicles
/
Calmodulin-Binding Proteins
/
Calmodulin
/
Calcium
/
Exocytosis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Neurosci Res
Journal subject:
NEUROLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Japan