Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.

Hayakawa, Masahiko; Kawaguchi, Ken-Ichi; Kaizawa, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi; Raynaud, Florence I; Parker, Peter; Workman, Paul; Waterfield, Michael D

Hayakawa, Masahiko; Kawaguchi, Ken-Ichi; Kaizawa, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Yamano, Mayumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi; Raynaud, Florence I; Parker, Peter; Workman, Paul; Waterfield, Michael D.

Affiliation

Hayakawa M; Drug Discovery Research, Astellas Pharma Inc, 5-2-3 Tokodai, Tsukuba, Ibaraki, Japan. masahiko.hayakawa@jp.astellas.com

Bioorg Med Chem ; 15(17): 5837-44, 2007 Sep 01.

Article in En | MEDLINE | ID: mdl-17601739

Subject(s)

Hydrazones/chemistry; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; Pyridines/chemical synthesis; Pyridines/pharmacology; Sulfur/chemistry; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Enzyme Activation/drug effects; Humans; Imidazoles/chemistry; Inhibitory Concentration 50; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Mice; Molecular Structure; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinase Inhibitors/chemistry; Protein Subunits/antagonists & inhibitors; Protein Subunits/metabolism; Pyridines/chemistry; Structure-Activity Relationship; Temperature; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Sulfur / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors / Hydrazones Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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