A timing-of-birth effect on multiple sclerosis clinical phenotype.
Neurology
; 69(1): 60-2, 2007 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-17606881
BACKGROUND: A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS). METHODS: Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive"). RESULTS: The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032). CONCLUSIONS: An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seasons
/
Multiple Sclerosis, Chronic Progressive
/
Multiple Sclerosis, Relapsing-Remitting
/
Parturition
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
America do norte
Language:
En
Journal:
Neurology
Year:
2007
Document type:
Article
Affiliation country:
Canada
Country of publication:
United States