Cathepsins/antagonists & inhibitors; Cathepsins/metabolism; Cysteine Endopeptidases/metabolism; Intestinal Neoplasms/etiology; Intestinal Neoplasms/genetics; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Animals; Base Sequence; Caco-2 Cells; Cathepsin L; Cathepsins/deficiency; Cathepsins/genetics; Cell Differentiation/drug effects; Cell Differentiation/physiology; Cell Line; Claudin-1; Cysteine Endopeptidases/deficiency; Cysteine Endopeptidases/genetics; Enzyme Activation/drug effects; Enzyme Activation/genetics; Gene Expression Regulation, Neoplastic/physiology; Genetic Predisposition to Disease; Humans; Intestinal Mucosa/cytology; Intestinal Mucosa/drug effects; Intestinal Mucosa/enzymology; Intestinal Neoplasms/metabolism; Membrane Proteins/physiology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Sequence Data; Protease Inhibitors/pharmacology; Rabbits; Up-Regulation/physiology