Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway.

Magne, Laurent; Blanc, Etienne; Marchand, Alexandre; Fafournoux, Pierre; Barouki, Robert; Rouach, Hélène; Garlatti, Michèle

Magne, Laurent; Blanc, Etienne; Marchand, Alexandre; Fafournoux, Pierre; Barouki, Robert; Rouach, Hélène; Garlatti, Michèle.

Affiliation

Magne L; INSERM U747, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Paris F-75006, France.

J Hepatol ; 47(5): 691-8, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17640761

Subject(s)

Ethanol/pharmacology; Hepatocytes/drug effects; Insulin-Like Growth Factor Binding Protein 1/genetics; JNK Mitogen-Activated Protein Kinases/drug effects; Liver/drug effects; RNA Stability/drug effects; Antioxidants/pharmacology; Carcinoma, Hepatocellular/metabolism; Cell Line, Tumor; Central Nervous System Depressants/pharmacology; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Enzyme Activation/genetics; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Hepatocytes/metabolism; Humans; Insulin-Like Growth Factor Binding Protein 1/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Liver/metabolism; Liver Neoplasms/metabolism; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; RNA Stability/genetics; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics; Up-Regulation/drug effects; Up-Regulation/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor Binding Protein 1 / RNA Stability / Hepatocytes / JNK Mitogen-Activated Protein Kinases / Ethanol / Liver Limits: Humans Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2007 Document type: Article Affiliation country: France Country of publication: Netherlands

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