Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome.

Chung, Ada W Y; Au Yeung, Karen; Sandor, George G S; Judge, Daniel P; Dietz, Harry C; van Breemen, Cornelis

Chung, Ada W Y; Au Yeung, Karen; Sandor, George G S; Judge, Daniel P; Dietz, Harry C; van Breemen, Cornelis.

Affiliation

Chung AW; Child and Family Research Institute, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. achung@mrl.ubc.ca

Circ Res ; 101(5): 512-22, 2007 Aug 31.

Article in En | MEDLINE | ID: mdl-17641224

Subject(s)

Aortic Aneurysm, Thoracic/physiopathology; Elastic Tissue/physiopathology; Marfan Syndrome/physiopathology; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/metabolism; Muscle, Smooth, Vascular/physiopathology; Actins/physiology; Animals; Aorta, Thoracic/physiopathology; Aortic Aneurysm, Thoracic/etiology; Disease Models, Animal; Elastic Tissue/pathology; Female; Fibrillin-1; Fibrillins; Male; Marfan Syndrome/complications; Mice; Microfilament Proteins/metabolism; Muscle Contraction/physiology; Muscle, Smooth, Vascular/pathology; Mutation; Up-Regulation/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Aortic Aneurysm, Thoracic / Matrix Metalloproteinase 2 / Matrix Metalloproteinase 9 / Elastic Tissue / Marfan Syndrome / Muscle, Smooth, Vascular Type of study: Etiology_studies Limits: Animals Language: En Journal: Circ Res Year: 2007 Document type: Article Affiliation country: Canada Country of publication: United States

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