The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion.

Kim, Nayoung; Saudemont, Aurore; Webb, Louise; Camps, Montserrat; Ruckle, Thomas; Hirsch, Emilio; Turner, Martin; Colucci, Francesco

Kim, Nayoung; Saudemont, Aurore; Webb, Louise; Camps, Montserrat; Ruckle, Thomas; Hirsch, Emilio; Turner, Martin; Colucci, Francesco.

Affiliation

Kim N; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.

Blood ; 110(9): 3202-8, 2007 Nov 01.

Article in En | MEDLINE | ID: mdl-17644738

Subject(s)

Cell Differentiation/genetics; Cytokines/metabolism; Killer Cells, Natural/cytology; Killer Cells, Natural/metabolism; Phosphatidylinositol 3-Kinases/physiology; Animals; Catalytic Domain/physiology; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Cytotoxicity, Immunologic/genetics; Female; Lymphocyte Count; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases/genetics; Protein Isoforms/physiology; Receptors, Cell Surface/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Cell Differentiation / Cytokines / Phosphatidylinositol 3-Kinases Limits: Animals Language: En Journal: Blood Year: 2007 Document type: Article Affiliation country: United kingdom Country of publication: United States

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