Acetyl Coenzyme A/drug effects; Acetylcholine/biosynthesis; Energy Metabolism/drug effects; Nerve Degeneration/chemically induced; Neurons/drug effects; Zinc/toxicity; Acetyl Coenzyme A/metabolism; Aconitate Hydratase/antagonists & inhibitors; Aconitate Hydratase/metabolism; Adenosine Triphosphate/metabolism; Animals; Cell Line, Tumor; Choline O-Acetyltransferase/antagonists & inhibitors; Choline O-Acetyltransferase/metabolism; Citric Acid Cycle/drug effects; Citric Acid Cycle/physiology; Dose-Response Relationship, Drug; Energy Metabolism/physiology; Enzyme Activation/drug effects; Enzyme Activation/physiology; Enzyme Inhibitors/toxicity; Glycolysis/drug effects; Glycolysis/physiology; Mice; Nerve Degeneration/metabolism; Nerve Degeneration/physiopathology; Neuroblastoma; Neurons/metabolism; Neurotoxins/toxicity; Pyruvate Dehydrogenase Complex/drug effects; Pyruvate Dehydrogenase Complex/metabolism; Thioctic Acid/analogs & derivatives; Thioctic Acid/pharmacology