An aluminum-based rat model for Alzheimer's disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration.

Walton, J R

Walton, J R.

Affiliation

Walton JR; Australian Institute for Biomedical Research, Sydney, NSW, Australia. j.walton@unsw.edu.au

J Inorg Biochem ; 101(9): 1275-84, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17662457

Subject(s)

Aluminum/toxicity; Alzheimer Disease/chemically induced; Disease Models, Animal; Oxidative Stress; Phosphoprotein Phosphatases/metabolism; Vacuoles/pathology; tau Proteins/metabolism; Alzheimer Disease/enzymology; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Animals; Brain/drug effects; Brain/enzymology; Brain/metabolism; Brain/pathology; Male; Neurofibrillary Tangles; Phosphorylation; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Vacuoles / Tau Proteins / Phosphoprotein Phosphatases / Oxidative Stress / Disease Models, Animal / Aluminum / Alzheimer Disease Limits: Animals Language: En Journal: J Inorg Biochem Year: 2007 Document type: Article Affiliation country: Australia

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