Non-transferrin-bound iron reaches mitochondria by a chelator-inaccessible mechanism: biological and clinical implications.

Shvartsman, Maya; Kikkeri, Raghavendra; Shanzer, Abraham; Cabantchik, Z Ioav

Shvartsman, Maya; Kikkeri, Raghavendra; Shanzer, Abraham; Cabantchik, Z Ioav.

Affiliation

Shvartsman M; Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Safra Campus at Givat Ram, Jerusalem, Israel.

Am J Physiol Cell Physiol ; 293(4): C1383-94, 2007 Oct.

Article in En | MEDLINE | ID: mdl-17670894

Subject(s)

Iron Chelating Agents/metabolism; Iron/metabolism; Mitochondria/metabolism; Aldehydes/metabolism; Animals; Biological Transport/drug effects; Cell Line; Cytosol/drug effects; Cytosol/metabolism; Deferoxamine/metabolism; Deferoxamine/pharmacology; Egtazic Acid/analogs & derivatives; Egtazic Acid/metabolism; Egtazic Acid/pharmacology; Fluoresceins/metabolism; Fluorescent Dyes/metabolism; Fluorometry; Hydrazones/metabolism; Iron Chelating Agents/pharmacology; Microscopy, Fluorescence; Models, Biological; Myocytes, Cardiac/cytology; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Protein Binding; Rhodamines/metabolism; Spectrometry, Fluorescence; Transferrin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Iron Chelating Agents / Iron / Mitochondria Limits: Animals Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2007 Document type: Article Affiliation country: Israel Country of publication: United States

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