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Nucleation and growth of apatite by a self-assembled polycrystalline bioceramic.
Karlinsey, Robert L; Yi, Keewook; Duhn, Clif W.
Affiliation
  • Karlinsey RL; Department of Preventive and Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN 46202, USA. rkarlins@iupui.edu
Bioinspir Biomim ; 1(1): 12-9, 2006 Mar.
Article in En | MEDLINE | ID: mdl-17671300
The formation aspects of a polycrystalline self-assembled bioceramic leading to the nucleation of hard-tissue mineral from a supersaturated solution are discussed. Scanning electron imaging and surface-sensitive interrogations of the nucleated mineral indicated the presence of an intermediate amorphous layer encompassing a rather crystalline phase that formed on niobium oxide (Nb(2)O(5)) microstructures. The crystalline phase was identified from Raman spectroscopy as hydroxyapatite (HAP), while the phosphorous-rich amorphous layer is suggested to have the chemical form CaO-P(2)O(5). In addition, the mechanism favoring HAP nucleation is discussed in terms of the (0 0 2) and (0 0 1) diffraction planes of HAP and Nb(2)O(5), respectively. The small mismatch along several lattice dimensions strongly suggests epitaxy as a dominant mode in the heterogeneous nucleation of HAP. Furthermore, the effectiveness of this mode was shown to critically depend on the self-organization of the Nb(2)O(5) microstructures. Because nucleation does not appear to depend solely on the integrity of Nb(2)O(5) crystals, the self-organization of Nb(2)O(5) crystals also contributes significantly to HAP nucleation. Based on our results, we propose the organized arrangement of bioceramic crystals as a new mode for the bioinspiration of hydroxyapatite and other hard-tissue mineral.
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Collection: 01-internacional Database: MEDLINE Main subject: Apatites / Ceramics / Crystallins / Biomimetic Materials / Niobium Language: En Journal: Bioinspir Biomim Journal subject: BIOLOGIA / ENGENHARIA BIOMEDICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Apatites / Ceramics / Crystallins / Biomimetic Materials / Niobium Language: En Journal: Bioinspir Biomim Journal subject: BIOLOGIA / ENGENHARIA BIOMEDICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom