Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly.

Spitzer, Dirk; Mitchell, Lynne M; Atkinson, John P; Hourcade, Dennis E

Spitzer, Dirk; Mitchell, Lynne M; Atkinson, John P; Hourcade, Dennis E.

Affiliation

Spitzer D; Division of Rheumatology, Department of Medicine, School of Medicine, Washington University, St. Louis, MO 63110, USA.

J Immunol ; 179(4): 2600-8, 2007 Aug 15.

Article in En | MEDLINE | ID: mdl-17675523

Subject(s)

Complement C3 Convertase, Alternative Pathway/chemistry; Complement Pathway, Alternative; Escherichia coli K12/chemistry; Lipopolysaccharides/chemistry; Neisseria gonorrhoeae/chemistry; Properdin/chemistry; Zymosan/chemistry; Animals; Antibodies/chemistry; Antibodies/genetics; Antibodies/metabolism; Complement C3 Convertase, Alternative Pathway/metabolism; Escherichia coli Infections/genetics; Escherichia coli Infections/metabolism; Escherichia coli K12/genetics; Escherichia coli K12/metabolism; Gonorrhea/metabolism; Humans; Lipopolysaccharides/metabolism; Mutation; Neisseria gonorrhoeae/metabolism; Properdin/genetics; Properdin/metabolism; Protein Binding; Rabbits; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sheep; U937 Cells; Zymosan/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Zymosan / Properdin / Lipopolysaccharides / Complement Pathway, Alternative / Escherichia coli K12 / Complement C3 Convertase, Alternative Pathway / Neisseria gonorrhoeae Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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